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Epigenetic deregulations of Wnt/β-catenin and transforming growth factor beta-Smad pathways in esophageal cancer: Outcome of DNA methylation.
Singh V, Singh AP, Sharma I, Singh LC, Sharma J, Borthakar BB, Rai AK, Kataki AC, Kapur S, Saxena S. Singh V, et al. J Cancer Res Ther. 2019 Jan-Mar;15(1):192-203. doi: 10.4103/jcrt.JCRT_634_17. J Cancer Res Ther. 2019. PMID: 30880778 Free article.
Significant interactions at protein level were found as VEGFA:PTK2, CTNNB1:CDH1, CTNNB1:VEGFA, CTNNB1:NEUROG1, CTNND2:CDH1, and CTNNB1:TERT. ...CONCLUSIONS: Deranged OPCML expression may lead to high-grade ESCC as well as epigenetically regulate …
Significant interactions at protein level were found as VEGFA:PTK2, CTNNB1:CDH1, CTNNB1:VEGFA, CTNNB1:NEUROG1, CTNND
Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population.
Singh V, Singh LC, Vasudevan M, Chattopadhyay I, Borthakar BB, Rai AK, Phukan RK, Sharma J, Mahanta J, Kataki AC, Kapur S, Saxena S. Singh V, et al. OMICS. 2015 Nov;19(11):688-99. doi: 10.1089/omi.2015.0121. Epub 2015 Oct 23. OMICS. 2015. PMID: 26496483
These included four genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, BMP8A, and IL22RA2) with p …
These included four genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNN
δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.
Nopparat J, Zhang J, Lu JP, Chen YH, Zheng D, Neufer PD, Fan JM, Hong H, Boykin C, Lu Q. Nopparat J, et al. Oncogene. 2015 Mar 19;34(12):1542-52. doi: 10.1038/onc.2014.89. Epub 2014 Apr 14. Oncogene. 2015. PMID: 24727894 Free PMC article.
Although beta-catenin and adenomatous polyposis coli (APC) gene mutations are well established and are known to drive tumorigenesis, discoveries of mutations in other components of the pathway lagged, which hinders the understanding of cancer mechanisms. Here we report that delta …
Although beta-catenin and adenomatous polyposis coli (APC) gene mutations are well established and are known to drive tumorigenesis, discove …